Isopropanol → (6-Allyl-5-chloropyrazolo[1,5-a]pyrimidin-7-yl)(4-ethoxyphenyl)amine
Reaktionsgleichung
C(O)(C)C.[CH2:5]([C:8]1[C:9]([Cl:18])=[N:10][C:11]2[N:12]([N:15]=[CH:16][CH:17]=2)[C:13]=1Cl)[CH:6]=[CH2:7].[CH3:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=1>C(N(CC)CC)C>[CH2:5]([C:8]1[C:9]([Cl:18])=[N:10][C:11]2[N:12]([N:15]=[CH:16][CH:17]=2)[C:13]=1[NH:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][CH2:20][CH3:19])=[CH:23][CH:24]=1)[CH:6]=[CH2:7]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
To an isopropanol (52 mL) solution containing 6-allyl-5,7-dichloropyrazolo[1,5-a]pyrimidine (5.98 g), triethylamine (12.7 mL) and phenethidine (4.30 g) were added, and this mixture was stirred at 40° C. for 5 hr. After the reaction, the solvent was distilled off. Saturated aqueous sodium hydrogen carbonate was added to the residue, and the mixture was extracted with ethyl acetate. The combined ethyl acetate layer was dried over sodium sulfate. After the sodium sulfate was filtered off, the filtrate was concentrated to obtain the title compound (8.62 g).
Aufarbeitung
- additionwere added
- customAfter the reaction
- distillationthe solvent was distilled off
- additionSaturated aqueous sodium hydrogen carbonate was added to the residue
- extractionthe mixture was extracted with ethyl acetate
- dry with materialThe combined ethyl acetate layer was dried over sodium sulfate
- filtrationAfter the sodium sulfate was filtered off
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-f59e88fd31274ea4be9ce626c26fb574
- Quelldatensatz
- uspto-grants-2009_01
- Patentnummer
- US07473694B2
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