(2-Aminobenzo[d]thiazol-6-yl)methanol → 2-Aminobenzo[d]thiazole-6-carbaldehyde

HRID 1452946Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1452946
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH2:11][OH:12])[CH:8]=[CH:7][C:5]=2[N:6]=1>C1COCC1.O=[Mn]=O>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1

Komponenten

4

Edukt 1

HCID 13821540(2-Aminobenzo[d]thiazol-6-yl)methanol

Produkt 1

HCID 138215412-Aminobenzo[d]thiazole-6-carbaldehydeAusbeute 87,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of (2-aminobenzo[d]thiazol-6-yl)methanol (1.90 g, 10.5 mmol, 1.0 eq.) in THF (75 mL) under nitrogen was added MnO2 (14 g, 161 mmol, 15.3 eq.). After stirring overnight, the reaction solution was filtered through Celite and rinsed with THF. The filtrate was concentrated in vacuo to give 2-aminobenzo[d]thiazole-6-carbaldehyde as a yellow solid (1.64 g, 87% yield).

Aufarbeitung

  1. filtrationthe reaction solution was filtered through Celite
  2. washrinsed with THF
  3. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d4c0a27c61424dd3a69e0b8ac9cbdd38
Quelldatensatz
uspto-grants-2009_01
Patentnummer
US07473784B2

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