Trimethyl orthoformate → HCID 68822180, Verbindung

Reaktionsgleichung

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH3:11])[C:6]=1[S:7]([NH2:10])(=[O:9])=[O:8].[CH:12](OC)(OC)OC>>[CH3:11][C:5]1[C:6]2[S:7](=[O:8])(=[O:9])[N:10]=[CH:12][NH:1][C:2]=2[S:3][CH:4]=1

Komponenten

Edukt 2

HCID 9005Trimethyl orthoformate

HCID 21999992HCID 21999992, Verbindung

Produkt 1

HCID 68822180HCID 68822180, Verbindung

Reaktionsbedingungen

Temperatur: 90 °C

Versuchsvorschrift

200 mg of 2-amino-4-methylthiophene-3-sulphonamide, the preparation of which is described in patent WO 99/03861, are dissolved in 1.5 ml of trimethyl orthoformate. The mixture is heated at 90° C. for 2 hours in an open vessel. After evaporation of the solvent under reduced pressure, the residue is taken up in 3 ml of ethyl acetate. The resulting insoluble material is collected by filtration, washed with diethyl ether and dried.

Aufarbeitung

customAfter evaporation of the solvent under reduced pressure
filtrationThe resulting insoluble material is collected by filtration
washwashed with diethyl ether
customdried

Quellen und Nachweise

ORD-Eintrag: ord-69695625111a4249ada7ca21d0cbfcf6
Quelldatensatz: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07476668B2

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