Hydrogen Peroxide → 2-tert-Butyl-1-oxo-1lambda~5~-pyridinato

HRID 1455342Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1455342
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:11]O>CC(O)=O.C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:11])([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 784Hydrogen PeroxideHCID 1386302-tert-Butylpyridine

Produkt 1

HCID 187150642-tert-Butyl-1-oxo-1lambda~5~-pyridinatoAusbeute 71,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Preparation C3, Step 1: 2-tert-butylpyridine (2.00 g, 14.8 mmol, 1 eq.) was dissolved in HOAc (10 mL) and 30% hydrogen peroxide (1.68 mL, 14.8 mmol, 1 eq.) at room temperature then the reaction was refluxed for 20 hours. The reaction was stripped to obtain an amber oil which was dissolved in methylene chloride (10 mL) then dried over sodium sulfate and stripped to obtain 2-tert-butylpyridine-N-oxide (1.60 g) as an amber oil. Yield=71.5%. LCMS detects (M+H)+=152.09.

Aufarbeitung

  1. customto obtain an amber oil which
  2. dry with materialthen dried over sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-e2b770de86f04b09beee93a9f9b05bbc
Quelldatensatz
uspto-grants-2009_01
Patentnummer
US07482335B2

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