1,2,3,6-Tetrahydropyridine → 1-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine
Reaktionsgleichung
[CH2:1]([O:5][C:6]1[C:11]([F:12])=[C:10](Cl)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4].[NH:14]1[CH2:19][CH:18]=[CH:17][CH2:16][CH2:15]1>>[CH2:1]([O:5][C:6]1[N:7]=[CH:8][N:9]=[C:10]([N:14]2[CH2:15][CH:16]=[CH:17][CH2:18][CH2:19]2)[C:11]=1[F:12])[C:2]#[C:3][CH3:4]Komponenten
3
Versuchsvorschrift
0.2 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine and 0.25 g of 1,2,3,6-tetrahydropyridine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.25 g of 1-(6-(2-butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine (hereinafter, referred to as Compound (53)).
Quellen und Nachweise
- ORD-Eintrag
- ord-83ad6d2e8682477ebd923d867eee68c3
- Quelldatensatz
- uspto-grants-2010_06