Formaldehyde → HCID 13748965, Verbindung

HRID 1455866

Reaktionsgleichung

Reaktionsgleichung von HRID 1455866
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH3:7][N:8]([CH2:10][C:11]1[CH:19]=[CH:18]C(C(O)=O)=[CH:13][CH:12]=1)[CH3:9].NCC1C=CC(C(OC)=O)=CC=1.C=O.[OH-].[Na+]>>[CH3:7][N:8]([CH2:10][C:11]1[CH:19]=[CH:18][C:1]([C:2]([Cl:4])=[O:3])=[CH:13][CH:12]=1)[CH3:9]

Komponenten

6

Edukt 5

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 65578Oxalyl chlorideHCID 571728Methyl 4-(aminomethyl)benzoateHCID 8263194-[(Dimethylamino)methyl]benzoic acid

Produkt 1

HCID 13748965HCID 13748965, Verbindung

Versuchsvorschrift

The 4-(N,N-dimethylaminomethyl) benzoyl chloride was prepared by reacting the acid with excess oxalyl chloride for 1 hr at 25° C. The 4-(N,N-dimethylaminomethyl) benzoic acid was in turn prepared from methyl 4-aminomethylbenzoate via reductive alkylation (CH2O, Na(OAc)3 BH as in J. Org. Chem., 1972, 37, 1673) followed by hydrolysis using 10% aqueous NaOH.

Aufarbeitung

  1. customfor 1 hr
  2. customat 25° C
  3. customfollowed by hydrolysis

Quellen und Nachweise

ORD-Eintrag
ord-d77ffea2c0ff485a9d1599781addece9
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05843905

Verknüpfte Notizen

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