1,1-Dimethylethyl 3,3-dimethyl-2-oxo-1-piperidinecarboxylate → 3,3-Dimethylpiperidin-2-one

HRID 1457220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1457220
[CH3:1][C:2]1([CH3:16])[CH2:7][CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[C:3]1=[O:15]>CO.Cl.CCOCC>[CH3:1][C:2]1([CH3:16])[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:15]

Komponenten

5

Edukt 1

HCID 572676081,1-Dimethylethyl 3,3-dimethyl-2-oxo-1-piperidinecarboxylate

Produkt 1

HCID 112404853,3-Dimethylpiperidin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

The title compound of Step (B) (440 mg, 1.94 mmol) in 4 ml MeOH and 15 ml 1N HCl in Et2O was stirred at room temperature overnight. The solvent was evaporated and dried in vacuo to provide the title compound of this step as a light yellow solid which was relatively pure and was used in the next step without further purification.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c0761b5ec2644a81975de9f8880552eb
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05846990

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