Water → HCID 23289956, Verbindung

HRID 1457525Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1457525
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[CH2:14]2)=[O:10].O>CN(C)C=O>[N:1]1([CH2:8][C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 8082PiperidineHCID 220993095-(Bromoacetyl)-1,3-dihydro-2H-indol-2-one

Produkt 1

HCID 23289956HCID 23289956, VerbindungAusbeute 49,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of piperidine (0.39 ml, 3.9 mmole) and 5-(2-bromoacetyl)-2-indolinone (500 mg, 1.97 mmole) in N,N-dimethylformamide (15 ml) was stirred at room temperature 4 h then was poured into water (50 ml) and washed with dichloromethane (250 ml), the organic solution was washed with water several times and dried over sodium sulfate. After evaporation of the solvent the residue was chromatographed on siiica-gel using ethyl acetate as eluant to give 5-(2-piperidin-1-yl-acetyl)-2-indolinone (250 mg).

Aufarbeitung

  1. washwashed with dichloromethane (250 ml)
  2. washthe organic solution was washed with water several times
  3. dry with materialdried over sodium sulfate
  4. customAfter evaporation of the solvent the residue
  5. customwas chromatographed on siiica-gel

Quellen und Nachweise

ORD-Eintrag
ord-2ec7ae9f58e54e2bb562f0ff5e9b9647
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05849710

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