Hydroxyamine hydrochloride → 4-(N-t-Butyloxycarbonylpiperidin-4-ylmethoxy)benzaldoxime

HRID 1457712Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1457712
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:25][OH:26]>CO.N1C=CC=CC=1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:23]=[CH:22][C:19]([CH:20]=[N:25][OH:26])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 443297Hydroxyamine hydrochlorideHCID 106393444-(N-t-Butyloxycarbonylpiperidin-4-ylmethoxy)benzaldehyde

Produkt 1

HCID 851794404-(N-t-Butyloxycarbonylpiperidin-4-ylmethoxy)benzaldoximeAusbeute 96,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22021344Pyridine methanolLösungsmittel

Versuchsvorschrift

A mixture of 4-(N-t-butyloxycarbonylpiperidin-4-ylmethoxy)benzaldehyde (3.16 g, 9.89 mmol) and hydroxylamine hydrochloride (1.27 g, 18.3 mmol) in 9:1 MeOH/pyridine (30 mL) was heated at reflux for 18 hours. The mixture was cooled to room temperature and concentrated to dryness. The residue was dissolved in EtOAc and washed with 0.1M HCl (3×), water, sat. CuSO4 (2×), water, sat. NaCl, dried (MgSO4) and concentrated, giving 3.19 g (96%) of the oxime; mp: 140.1°-141.8° C.; 1H NMR (300 MHz, CDCl3) δ 8.07 (s, 1H), 7.48 (d, J=8.8 Hz, 2H), 6.86 (d, J=8.8 Hz, 2H), 4.14 (bs, 2H), 3.80 (d, J=6.2 Hz, 2H), 2.71 (bt, J=12.4 Hz, 2H), 1.95 (m, 1H), 1.80 (bd, J=12.4 Hz, 2H), 1.45 (s, 9H), 1.26 (m, 2H).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 18 hours
  3. concentrationconcentrated to dryness
  4. dissolutionThe residue was dissolved in EtOAc
  5. washwashed with 0.1M HCl (3×), water, sat. CuSO4 (2×), water, sat. NaCl
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0f0d63f0860344f4b7e38d5fb561d8c1
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05849736

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