Methyl tetrahydro-2,5-dimethoxyfuroate → 1-Cyclohexyl-6-trifluoromethyl-7-(2-methoxycarbonyl-1-pyrrolyl)-2,3(1H,4H)-quinoxalinedione

HRID 1458800Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1458800
CO[C:3]([C:5]1(OC)[CH2:9][CH2:8][CH:7]([O:10][CH3:11])[O:6]1)=O.[CH:14]1([N:20]2[C:29]3[C:24](=[CH:25][C:26]([C:31]([F:34])([F:33])[F:32])=[C:27]([NH2:30])[CH:28]=3)[NH:23][C:22](=[O:35])[C:21]2=[O:36])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>COC1CCC(OC)O1.C(O)(=O)C>[CH:14]1([N:20]2[C:29]3[C:24](=[CH:25][C:26]([C:31]([F:32])([F:33])[F:34])=[C:27]([N:30]4[CH:3]=[CH:5][CH:9]=[C:8]4[C:7]([O:10][CH3:11])=[O:6])[CH:28]=3)[NH:23][C:22](=[O:35])[C:21]2=[O:36])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1

Komponenten

5

Edukt 2

HCID 13152840Methyl tetrahydro-2,5-dimethoxyfuroateHCID 220971171-cyclohexyl-6-trifluoromethyl-7-amino-2,3(1H,4H)-quinoxalinedione

Produkt 1

HCID 220972281-Cyclohexyl-6-trifluoromethyl-7-(2-methoxycarbonyl-1-pyrrolyl)-2,3(1H,4H)-quinoxalinedione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 790982,5-DimethoxytetrahydrofuranLösungsmittel

Versuchsvorschrift

In place of 2,5-dimethoxytetrahydrofuran, 1.2 g (6.1 mmol) of 2-methoxycarbonyl-2,5-dimethoxytetrahydrofuran were dissolved with 2 g (6.1 mmol) of 1-cyclohexyl-6-trifluoromethyl-7-amino-2,3(1H,4H)-quinoxalinedione in 100 ml of acetic acid and refluxed for 30 minutes. The mixture was then worked up as in Example 3f.

Aufarbeitung

  1. temperaturerefluxed for 30 minutes

Quellen und Nachweise

ORD-Eintrag
ord-54097fc6617a49e38877261bda276948
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05852017

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