4-Chlorobenzylamine → Nicotinic acid, 2-(p-chlorobenzylamino)-

HRID 1459449Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1459449
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH2:17])=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH:17][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[CH:14][CH:13]=1

Komponenten

3

Edukt 2

HCID 660364-ChlorobenzylamineHCID 762582-Chloronicotinic acid

Produkt 1

HCID 214597Nicotinic acid, 2-(p-chlorobenzylamino)-

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of 2-chloronicotinic acid (30.0 g) and 4-chlorobenzylamine (45 ml) was heated at 120° C. for 3.5 hours. The mixture was cooled to ambient temperature and the solid obtained was washed with water and collected by filtration. The solid was boiled in methanol and filtered to give 2-(4-chlorobenzylamino)-nicotinic acid, m.p. 240°-242° C.

Aufarbeitung

  1. temperatureThe mixture was cooled to ambient temperature
  2. customthe solid obtained
  3. washwas washed with water
  4. filtrationcollected by filtration
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-ec2ac6cea6f04b0d807284ac0a9c537e
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05854257

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