1,2-Cyclopentanedicarboxylic acid, (1R,2R)-rel- → cis-tetrahydro-1H-cyclopenta[c]furan-1,3(4H)-dione

HRID 1459692

Reaktionsgleichung

[C@@H:1]1([C:9]([OH:11])=[O:10])[CH2:5][CH2:4][CH2:3][C@H:2]1[C:6]([OH:8])=O>C(OC(=O)C)(=O)C>[C@@H:2]12[C:6](=[O:8])[O:11][C:9](=[O:10])[C@@H:1]1[CH2:5][CH2:4][CH2:3]2

Komponenten

Reaktionsbedingungen

Temperatur: 165 °C

Versuchsvorschrift

To the trans-cyclopentane-1,2-dicarboxylic acid (1.16 g, 7.33 mmol) at room temperature, was added Acetic anhydride (10 mL, ex). The reaction mixture was refluxed at about 165° C. for 14 hrs. Workup consisted of concentration in vacuo and co-evaporation with toluene three times. The crude product (1.0 g, ~100%, with a little impurity of Acetic anhydride) was given as a brown oily solid.

Aufarbeitung

concentrationWorkup consisted of concentration in vacuo and co-evaporation with toluene three times

Quellen und Nachweise

ORD-Eintrag: ord-c6c346c9c0b84a029fcbb366463e072d
Quelldatensatz: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05854277

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