Triethylamine → HCID 19981929, Verbindung

HRID 1460492Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1460492
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][N:10]=1.C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][N:10]=1)(=[O:4])=[O:3]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 154753442-(Pyrimidin-4-yl)ethanol

Produkt 1

HCID 19981929HCID 19981929, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of methanesulphonyl chloride (137 mg) in dichloromethane (2 ml) was added to a solution of 4-(2-hydroxyethyl)pyrimidine (124 mg) (prepared by the method of C. G. Overberger and I. C. Kogon, JACS, 76, 1879 (1954)) and triethylamine (121 mg) in dichloromethane (10 ml), the mixture stirred at room temperature for 3 hours and evaporated under reduced pressure to give the crude title compound as a pale yellow oil which was used directly in Example 10 without further purification.

Aufarbeitung

  1. customprepared by the method of C
  2. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5ca7e4b745864d64be87d29d6ffcf93d
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05071844

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