Water → Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate

HRID 1460775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1460775
[CH2:1]([N:4]([CH2:10][CH:11]=O)[C:5](=[O:9])[O:6][CH2:7][CH3:8])[CH:2]=[CH2:3].O.[NH:14]1[CH2:17][CH2:16][CH:15]1C(O)=O>C1(C)C=CC=CC=1>[N:14]12[CH2:17][CH2:16][CH:15]1[CH2:3][CH:2]1[CH:11]2[CH2:10][N:4]([C:5]([O:6][CH2:7][CH3:8])=[O:9])[CH2:1]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 17288Azetidinecarboxylic AcidHCID 11084330Ethyl allyl(2-oxoethyl)carbamate

Produkt 1

HCID 54190177Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

17.1 g (0.1 mol) of ethyl N-allyl-N-(2-oxoethyl) -carbamate are heated under reflux overnight in a water separator with 10 g (0.1 mol) of azetidine-2-carboxylic acid in 200 ml of toluene. Unreacted amino acid is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Aufarbeitung

  1. filtrationUnreacted amino acid is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-2faa50c541fd4399b611f0b5861af91e
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05071999

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