2-Nitro-2-phenyl-1,3-propanediol → 2-Phenyl-1,3-propanediol

HRID 1460866

Reaktionsgleichung

Reaktionsgleichung von HRID 1460866
[N+]([C:4]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH2:7][OH:8])[CH2:5][OH:6])([O-])=O.[H][H]>[Pd].CO>[C:9]1([CH:4]([CH2:5][OH:6])[CH2:7][OH:8])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

5

Edukt 2

HCID 2243932-Nitro-2-phenyl-1,3-propanediolHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 2541782-Phenyl-1,3-propanediol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

12 g. (0.06 mole) of 2-nitro-2-phenyl-1,3-propanediol, 400 mg. of 5% palladium on calcium carbonate and 150 ml. of methanol are placed in a Parr hydrogenator bottle and reduced with hydrogen overnight. The mixture is filtered through Celite, concentrated to an oil and recrystallized from 30 ml. of toluene. The yield is 7.4 g. (80%) of product, M.P. 52°-4° C.

Aufarbeitung

  1. filtrationThe mixture is filtered through Celite
  2. concentrationconcentrated to an oil
  3. customrecrystallized from 30 ml

Quellen und Nachweise

ORD-Eintrag
ord-ae0c7467800240ea8e0b36f915f90841
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05072056

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