HCID 15675385, Verbindung → 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole

HRID 1461270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1461270
[N:1]([CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:15])=[N+]=[N-].[H][H]>C(O)C.O.[C].[Pd]>[NH2:1][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:15]

Komponenten

6

Edukt 2

HCID 15675385HCID 15675385, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 117451761-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazoleAusbeute 89,1 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

In 150 ml of ethanol was dissolved 1.3 g (6.4 mmol) of Compound i followed by addition of a suspension of 65 mg (5 w/w%) of 10% palladium-carbon in 2 ml of water. The mixture was stirred at room temperature for 4.5 hours, with hydrogen gas being bubbled into the mixture. The reaction mixture was then filtered and the filtrate was concentrated to give 1.01 g (89.1%) of 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole (Compound j) as white crystals.

Aufarbeitung

  1. custombeing bubbled into the mixture
  2. filtrationThe reaction mixture was then filtered
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-74fff30f668c4f55893006e613832f27
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05075301

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