Deferoxamine Mesylate → N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxo-butanoyl]-hydroxy-amino]pentyl]-N'-(5-aminopentyl)-N'-hydroxy-butanediamide; zinc

HRID 1461554Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1461554
[CH3:1][C:2]([N:4]([OH:39])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([CH2:13][CH2:14][C:15]([N:17]([OH:38])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([CH2:26][CH2:27][C:28]([N:30]([OH:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])=[O:29])=[O:25])=[O:16])=[O:12])=[O:3].CS(O)(=O)=O.[Cl-].[Cl-].[Zn+2:47]>>[Zn:47].[CH3:1][C:2]([N:4]([OH:39])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([CH2:13][CH2:14][C:15]([N:17]([OH:38])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([CH2:26][CH2:27][C:28]([N:30]([OH:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])=[O:29])=[O:25])=[O:16])=[O:12])=[O:3]

Komponenten

3

Edukt 2

HCID 62881Deferoxamine MesylateHCID 3007855Zincchloride

Produkt 1

HCID 473262N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxo-butanoyl]-hydroxy-amino]pentyl]-N'-(5-aminopentyl)-N'-hydroxy-butanediamide; zinc

Versuchsvorschrift

10 mM solution of Desferal (Ciba-Geigy, Basle) is mixed with an equal volume of 10 mM solution of ZnCl2 (A. R. Aldrich Chemical Co., Inc.) solution, titrated to pH 7.4. The mixture is heated for 30 min. to 45° C., and cooled and the complex Zn/Desferrioxamine B is formed. The ratio Zn:Desferal is 1.0:1.0.

Aufarbeitung

  1. temperatureThe mixture is heated for 30 min. to 45° C.
  2. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-9b48318f39834b92aae0d2a02abc1227
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05075469

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