1(2H)-Phthalazinone → HCID 19979310, Verbindung

HRID 1461746Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1461746
[OH-].[K+].[O:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][NH:5]1.Br[CH2:15][CH2:16][O:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][O:19]1>O.CS(C)=O>[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH:18]1[O:17][CH2:16][CH2:15][N:5]1[N:6]=[CH:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]1=[O:3]

Komponenten

6

Edukt 3

HCID 83941(2H)-PhthalazinoneHCID 14797Potassium HydroxideHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyran

Produkt 1

HCID 19979310HCID 19979310, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 41.5 g of potassium hydroxide in 53 ml of water is added at room temperature to a solution of 61 g of 1-oxophthalazine in 430 ml of dimethyl sulfoxide. After 30 minutes, 130 g of tetrahydro-2-pyranyl 2-bromoethyl ether are added to the suspension obtained. The mixture is left stirring for 30 hours at room temperature and then concentrated, the residue is taken up in 400 ml of water and the product is extracted with dichloromethane. The organic phase is concentrated.

Aufarbeitung

  1. customobtained
  2. waitThe mixture is left
  3. concentrationconcentrated
  4. extractionthe product is extracted with dichloromethane
  5. concentrationThe organic phase is concentrated

Quellen und Nachweise

ORD-Eintrag
ord-725db703735c4a669a505d486e532aa0
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05077288

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