Diethyl Ether → 3-Methyl-2-[[3-[acetyl[2-[4-(tetradecyloxy)phenyl]ethyl]amino]phenyl]methyl]thiazolium iodide

HRID 1461934Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1461934
[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][N:24]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][C:35]3[S:36][CH:37]=[CH:38][N:39]=3)[CH:29]=2)[C:25](=[O:27])[CH3:26])=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].C[I:41].[CH3:42]COCC>C1(C)C=CC=CC=1>[I-:41].[CH3:42][N+:39]1[CH:38]=[CH:37][S:36][C:35]=1[CH2:34][C:30]1[CH:31]=[CH:32][CH:33]=[C:28]([N:24]([C:25](=[O:27])[CH3:26])[CH2:23][CH2:22][C:19]2[CH:18]=[CH:17][C:16]([O:15][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[CH:21][CH:20]=2)[CH:29]=1

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 15030169HCID 15030169, Verbindung

Produkt 1

HCID 150301563-Methyl-2-[[3-[acetyl[2-[4-(tetradecyloxy)phenyl]ethyl]amino]phenyl]methyl]thiazolium iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

A mixture of 300 mg of N-[2-[4-(tetradecyloxy)phenyl]ethyl]-N-[3-(2-thiazolylmethyl)phenyl]acetamide and 1.4 g of methyl iodide in 5 ml of toluene is heated at 140° C. in a closed vessel for 4.5 hours then cooled. Ether is added, the solid collected by centrifugation and then washed several times with ether. The solid is vacuum dried to give 235 mg of the desired product as a tan solid, m.p. 130°-134° C.

Aufarbeitung

  1. temperaturethen cooled
  2. customthe solid collected by centrifugation
  3. washwashed several times with ether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0dc4ce2c0ec84118bd13303b7ca52038
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05077409

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