Phosphoric Acid → HCID 2802466, Verbindung

HRID 1462947

Reaktionsgleichung

Reaktionsgleichung von HRID 1462947
[OH:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[C:4](=[O:14])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.P(=O)(O)(O)O>COCCO.O>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]([CH:6]2[CH2:5][C:4](=[O:14])[C:3]3[C:2](=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:1]2)=[CH:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 1004Phosphoric AcidHCID 6172491-(2-Hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one

Produkt 1

HCID 2802466HCID 2802466, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 80192-MethoxyethanolLösungsmittel

Versuchsvorschrift

The 2'-Hydroxy-4-methylchalcone of Example 13 (7.3 g.) was boiled under reflux with a solution of 85% phosphoric acid (22 ml.) in 2-methoxyethanol (219 ml.) for 8 hrs. The reaction mixture was diluted with water (1 liter) and the oily precipitate extracted into dichloromethane (300 ml.). The organic extract was separated and washed with water and saturated sodium bicarbonate solution. Filtration and evaporation gave a residue of 4'-methylflavanone contaminated with the starting chalcone.

Aufarbeitung

  1. extractionthe oily precipitate extracted into dichloromethane (300 ml.)
  2. extractionThe organic extract
  3. customwas separated
  4. washwashed with water and saturated sodium bicarbonate solution
  5. filtrationFiltration and evaporation

Quellen und Nachweise

ORD-Eintrag
ord-384e663e01314cf0b77e10d0f218e8a6
Quelldatensatz
uspto-grants-1984_07
Patentnummer
US04461907

Verknüpfte Notizen

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