Ethanesulfonyl chloride → [(Ethylsulfonyl)amino[methyl]-1H-indol-3-yl]propyl-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Ethanesulfonyl chloride	HCID 11667	—
Edukt	1-(5-Methoxy-4-pyrimidinyl)-2-methylpiperazine	HCID 19081474	—
Edukt	1-[[5-[[(ethylsulfonyl)amino]methyl]-1H-indol-3-yl]propyl]-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine	HCID 54519656	—
Produkt	[(Ethylsulfonyl)amino[methyl]-1H-indol-3-yl]propyl-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine	HCID 86747728	—

Reaktionsschritte

In a similar manner to Example 32 1-[[5-[[(ethylsulfonyl)amino]methyl]-1H-indol-3-yl]propyl]-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine was synthesized by utilizing 1-(5-methoxy-4-pyrimidinyl)-2-methylpiperazine in the coupling step and ethanesulfonyl chloride in the sulfonylation step: C24H34N6O3S/2.9 HCl, m.p. 202°-210° C. Elemental analysis calculated: C, 48.66; H, 6.28; N, 14.19; found: C, 48.41; H, 6.35; N, 13.93.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05300506
Quelldatensatz	uspto-grants-1994_04
ORD ID	ord-f45445771a204e65b92a639b93e00413
Quellennotiz	uspto-grants-1994_04