2,4-Difluoroaniline → 2,4-Difluorophenyl-3-methylurea
Reaktionsgleichung
[CH3:1][N:2]=[C:3]=[O:4].[F:5][C:6]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:7]=1[NH2:8]>C1(C)C=CC=CC=1>[F:5][C:6]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:7]=1[NH:8][C:3]([NH:2][CH3:1])=[O:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Methyl isocyanate (9.6 g, 10 mL, 0.174 mol) is added to a solution of 2,4-difluoroaniline (15 g, 0.116 mol) in toluene. The reaction mixture is stirred for 1 hour and filtered to obtain a solid. The solid is washed with hexanes and air-dried to give the title product as an off-white solid, mp 182°-183° C.
Aufarbeitung
- filtrationfiltered
- customto obtain a solid
- washThe solid is washed with hexanes
- customair-dried
Quellen und Nachweise
- ORD-Eintrag
- ord-2711ddf9e8434df4b8105ee87a87cff2
- Quelldatensatz
- uspto-grants-1998_03
- Patentnummer
- US05726126
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