Potassium Hydroxide → 2-Hydroxy-5-[2-[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoic acid

HRID 1464170Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1464170
[OH:1][C:2]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][C:17]2[CH:22]=[CH:21][C:20]([S:23]([NH:26][C:27]3[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][N:28]=3)(=[O:25])=[O:24])=[CH:19][CH:18]=2)=[CH:11][C:3]=1[C:4]([O:6]CC(C)C)=[O:5].[OH-].[K+].S([O-])([O-])=O.[Na+].[Na+]>O>[OH:1][C:2]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][C:17]2[CH:18]=[CH:19][C:20]([S:23]([NH:26][C:27]3[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][N:28]=3)(=[O:25])=[O:24])=[CH:21][CH:22]=2)=[CH:11][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 3

HCID 14797Potassium HydroxideHCID 24437Sodium SulfiteHCID 54356729Isobutyl 2-hydroxy-5-[2-[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoate

Produkt 1

HCID 544094842-Hydroxy-5-[2-[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The product from Example 12c (78 g) was added to a solution of potassium hydroxide (50 g, 0.78 mol) in water (600 mi) and the mixture was refluxed overnight. After addition of activated carbon (2 g) and sodium sulfite (0.5 g) the mixture was allowed to cool, with s&%g to room temperature and then filtered.

Aufarbeitung

  1. temperaturethe mixture was refluxed overnight
  2. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-6aa438f45db143c99ef1cb234ebb90f5
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05302718

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