3-Oxobutyronitrile → HCID 86747770, Verbindung

HRID 1464266

Reaktionsgleichung

Reaktionsgleichung von HRID 1464266
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][N:3]=1.[C:10]([CH2:12][C:13](=O)[CH3:14])#[N:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:13]([CH3:14])=[CH:12][C:10]#[N:11])=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 755793-OxobutyronitrileHCID 70209275-(Aminomethyl)-2-chloropyridine

Produkt 1

HCID 86747770HCID 86747770, VerbindungAusbeute 85 %

Versuchsvorschrift

1.4 g of 2-chloro-5-pyridylmethylamine and 0.8 g of 1-cyano-2-propanone were mixed and the mixture was stirred at room temperature over night. The solvent was then distilled off and the residue was purified by column chromatography on silica gel to afford 1.7 g of compound No. 528. m.p. 95°-98° C.

Aufarbeitung

  1. distillationThe solvent was then distilled off
  2. customthe residue was purified by column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-0787945b338f4211b0c021907cfd5215
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05304566

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