Sodium Hydroxide → 3,5-Dichloro-4-cyanobenzamide

To a well stirred mixture of 4-cyano-3,5-dichlorobenzoyl chloride (4.0 g, 0.017 mol) and water (100 ml) at 0° C. (ice-water bath) were added 3-amino-3-methyl-1-pentyne hydrochloride and 50 weight percent aqueous sodium hydroxide (10 ml). The resulting mixture was stirred 1 hour at 0° C., warmed up to room temperature and extracted with ethyl acetate (3×50 ml), the combined organic layers were washed with water (3×50 ml), and then dried over anhydrous sodium sulfate. The solvent was then eliminated in the rotavap, yielding the crude product as a yellow oil (2.79 g). The crude product was purified by Michel-Miller chromatographic column packed with Merck (grade 60) silica gel using ethyl acetate as solvent, yielding 0.75 g of N-[3'-methyl-1'-pentynyl)]-4-cyano-3,5-dichlorobenzamide.

1. stirringThe resulting mixture was stirred 1 hour at 0° C.
2. extractionextracted with ethyl acetate (3×50 ml)
3. washthe combined organic layers were washed with water (3×50 ml)
4. dry with materialdried over anhydrous sodium sulfate
5. customyielding the crude product as a yellow oil (2.79 g)
6. customThe crude product was purified by Michel-Miller chromatographic column

ORD-Eintrag

ord-4c97cb8ba78e494395d3544731ab85ec

Quelldatensatz

uspto-grants-1994_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05304572