Dimethylamine → Cgp13501

HRID 1464475

Reaktionsgleichung

Reaktionsgleichung von HRID 1464475
[CH3:1][C:2]([CH3:7])([CH2:5][OH:6])[CH:3]=O.O.[C:9]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:14]=1[OH:23])([CH3:12])([CH3:11])[CH3:10].CNC>CO>[C:19]([C:15]1[CH:16]=[C:17]([CH2:3][C:2]([CH3:1])([CH3:7])[CH:5]=[O:6])[CH:18]=[C:13]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:14]=1[OH:23])([CH3:22])([CH3:21])[CH3:20]

Komponenten

6

Edukt 4

HCID 674DimethylamineHCID 962WaterHCID 116993-Hydroxy-2,2-dimethylpropionaldehydeHCID 314052,6-Di-tert-butylphenol

Produkt 1

HCID 3519541Cgp13501Ausbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

125 g (1 mol) of 80% strength aqueous 2,2-dimethyl-3-hydroxypropanal (crude mixture from the synthesis, reduced to a water content of 20% by distillation), 185 g (0.9 mol) of 2,6-di-t-butylphenol, 12 g (0.11 mol) of 40% strength aqueous dimethylamine and 700 g of methanol are reacted in a stirred autoclave at 180° C. and under the autogenous pressure of 20-30 bar for 10 h. Workup of the reaction mixture by distillation yields 238 g (92%) of 3-(3,5-di-t-butyl-4-hydroxyphenyl)-2,2-dimethylpropanal (boiling point 126°-127° C.; melting point 75°-77° C.).

Aufarbeitung

  1. customare reacted in a stirred autoclave at 180° C. and under the autogenous pressure of 20-30 bar for 10 h
  2. distillationWorkup of the reaction mixture by distillation

Quellen und Nachweise

ORD-Eintrag
ord-ffe35f3548254c289f1b10504ffbe605
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05304685

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