Ethanol → 2-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde

HRID 1464611

Reaktionsgleichung

Reaktionsgleichung von HRID 1464611
C[O:2][CH:3](OC)[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:12][CH2:11]2)[CH:7]=[CH:6][C:5]=1[N+:20]([O-:22])=[O:21].C=O.C(O)C>Cl.O>[N+:20]([C:5]1[CH:6]=[CH:7][C:8]([N:10]2[CH2:11][CH2:12][CH:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:14][CH2:15]2)=[CH:9][C:4]=1[CH:3]=[O:2])([O-:22])=[O:21]

Komponenten

6

Edukt 3

HCID 702EthanolHCID 712FormaldehydeHCID 190868632-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal

Produkt 1

HCID 190868462-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

0.3 Gram of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal, 5 ml of formalin, 1 ml of ethanol and 2 drops of concentrated hydrochloric acid were refluxed by heating. After the reaction was completed, the solvent was removed by evaporation to obtain the residue, then water was added to the residue. The crystals formed were collected by filtration to yield 0.22 g of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde.

Aufarbeitung

  1. temperatureby heating
  2. customthe solvent was removed by evaporation
  3. customto obtain the residue
  4. customThe crystals formed
  5. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-24500cb7809f4f38bdc83cb7fb68bc53
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05306719

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