Acetic Anhydride → N-(4-Phenoxyphenyl)acetamide

HRID 1466469Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1466469
[O:1]([C:8]1[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:22](OC(=O)C)(=[O:24])[CH3:23]>ClCCl>[O:1]([C:8]1[CH:9]=[CH:10][C:11]([NH:12][C:22](=[O:24])[CH3:23])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 8764(4-Aminophenoxy)benzene

Produkt 1

HCID 80579N-(4-Phenoxyphenyl)acetamideAusbeute 89,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Commercial available 4-phenoxy-aniline (4.16 g, 20.8 mmol) was dissolved in dichloromethane (100 mL), and triethylamine (3.05 g, 31.1 mmol) and acetic anhydride (2.22 g, 20.8 mmol) were added in drops. The mixture was stirred for 1 h at 0° C. to room temperature. After completion of the reaction, the mixture was filtered using dichloromethane and crystallized to give the title compound (4.50 g, 18.6 mmol)

Aufarbeitung

  1. customAfter completion of the reaction
  2. filtrationthe mixture was filtered
  3. customcrystallized

Quellen und Nachweise

ORD-Eintrag
ord-137788353f0e4acfaa18cbfa46c1847f
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000028B2

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