Ethyl Acetoacetate → Ethyl 4-amino-2-methyl-5-(piperidin-3-ylmethoxy)quinoline-3-carboxylate

HRID 1467111

Reaktionsgleichung

Reaktionsgleichung von HRID 1467111
[NH2:1][C:2]1[C:3]([C:26]#[N:27])=[C:4]([CH:23]=[CH:24][CH:25]=1)[O:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][N:9](C(OCC2C=CC=CC=2)=O)[CH2:8]1.O=[C:29]([CH3:36])[CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[NH2:27][C:26]1[C:3]2[C:2](=[CH:25][CH:24]=[CH:23][C:4]=2[O:5][CH2:6][CH:7]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8]2)[N:1]=[C:29]([CH3:36])[C:30]=1[C:31]([O:33][CH2:34][CH3:35])=[O:32]

Komponenten

3

Edukt 2

HCID 8868Ethyl AcetoacetateHCID 66747031HCID 66747031, Verbindung

Produkt 1

HCID 66746012Ethyl 4-amino-2-methyl-5-(piperidin-3-ylmethoxy)quinoline-3-carboxylate

Versuchsvorschrift

Prepared as in Example 2a from benzyl 3-((3-amino-2-cyanophenoxy)methyl)piperidine-1-carboxylate (Example 110c) and ethyl 3-oxobutanoate as a yellow oil (21%). MS 344 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-2d29e8e324834ff7a0bd509147f0b6a4
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000054B2

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