2,4-Dichloropyrimidine → 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

HRID 14701

Reaktionsgleichung

Reaktionsgleichung von HRID 14701
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][CH:16]=1)=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:15]2[CH:16]=[C:11]([CH:12]=[CH:13][CH:14]=2)[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 775312,4-DichloropyrimidineHCID 27343563-Formylphenylboronic acid

Produkt 1

HCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehydeAusbeute 60 %

Versuchsvorschrift

2,4 dichloropyrimidine and 3-formyl phenyl boronic acid were coupled following procedure A. The yield was 60%. LC-MS showed the product was >95% pure and had the expected M+H+ of 219. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 610.1 (s, 1H) 8.7 (d, 1H) 8.6 (m, 1H) 8.4 (m, 1H) 8.1 (m, 1H) 7.7 (m, 2H).

Quellen und Nachweise

ORD-Eintrag
ord-e0e0050b65ba4b42a63f0cab5037d450
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732444B2

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