1-(2-Hydroxyethyl)piperazine → HCID 57516914, Verbindung

HRID 1472574Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1472574
F[C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=1)[C:7]([NH:9][CH3:10])=[O:8].[OH:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.CCN(C(C)C)C(C)C>CN(C=O)C>[OH:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:2]2[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=2)[C:7]([NH:9][CH3:10])=[O:8])[CH2:20][CH2:19]1

Komponenten

5

Edukt 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 81531DiisopropylethylamineHCID 442030775-Fluoro-N-methyl-2-nitrobenzamide

Produkt 1

HCID 57516914HCID 57516914, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 5-fluoro-N-methyl-2-nitrobenzamide, 1-(2-hydroxyethyl)piperazine, and Hunig's base in 20 mL of DMF was stirred at room temperature over the weekend. The resulting mixture was rotavaped to dryness, and the residue was purified by flash column SF40-150 at 2%-10% MeOH/CH2Cl2. Product came out at 7% MeOH/CH2Cl2. MS (ES) m/e 309 [M+H].

Aufarbeitung

  1. customthe residue was purified by flash column

Quellen und Nachweise

ORD-Eintrag
ord-fad57bbf56a94b28a266fa02c889d41c
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09012479B2

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