Urea → 6-METHOXYQUINAZOLINE-2,4-DIOL

HRID 1472718Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1472718
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:13][C:14](N)=[O:15]>O>[CH3:12][O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[NH:1][C:14](=[O:15])[NH:13][C:4]2=[O:6]

Komponenten

4

Edukt 2

HCID 1176UreaHCID 2779305-Methoxyanthranilic acid

Produkt 1

HCID 103302006-METHOXYQUINAZOLINE-2,4-DIOLAusbeute 88,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

A mixture of 2-amino-5-methoxybenzoic acid (5.00 g, 29.9 mmol) and urea (5.40 g, 90.0 mmol) was heated to 200° C. for 1 hour. The mixture was cooled to room temperature and diluted with H2O (50 mL), the mixture was filtered off and the precipitate was washed with H2O (10 mL), dried in vacuo to give the product (5.10 g, yield 88%).

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe mixture was filtered off
  3. washthe precipitate was washed with H2O (10 mL)
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0e2959cd25884f7cb48f6ce16e6d964d
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09012646B2

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