Water → 2-(2-bromo-5-(trifluoromethyl)phenyl)-1-methyl-1H-imidazole

HRID 1473361Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1473361
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[Sn](CCCC)(CCCC)CCCC.[Br:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=1I.[F-].[K+].O>CN(C=O)C.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C(Cl)Cl>[Br:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]([F:28])([F:29])[F:30])=[CH:25][C:26]=1[C:3]1[N:2]([CH3:1])[CH:6]=[CH:5][N:4]=1

Komponenten

7

Edukt 4

HCID 962WaterHCID 522689Potassium FluorideHCID 27632521-Methyl-2-(tributylstannyl)-1H-imidazoleHCID 467352311-Bromo-2-iodo-4-(trifluoromethyl)benzene

Produkt 1

HCID 866874082-(2-bromo-5-(trifluoromethyl)phenyl)-1-methyl-1H-imidazoleAusbeute 64,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418807HCID 178418807, VerbindungKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of PdCl2(dppf)-CH2Cl2 adduct (0.233 g, 0.285 mmol), 1-methyl-2-(tributylstannyl)imidazole (2.189 ml, 6.84 mmol), 1-bromo-2-iodo-4-(trifluoromethyl)benzene (0.919 ml, 5.70 mmol), and potassium fluoride (1.656 g, 28.5 mmol) in 6 mL DMF was heated to 80° C. overnight. LC/MS showed product, so the reaction mixture was poured into water and was extracted with DCM. The organics were dried over MgSO4 and concentrated. Purification of the crude residue by silica gel column chromatography (0 to 100% EtOAc/heptane) gave 2-(2-bromo-5-(trifluoromethyl)phenyl)-1-methyl-1H-imidazole (1.122 g, 3.68 mmol, 64.5% yield). m/z (ESI) 307.2 (M+H)+.

Aufarbeitung

  1. extractionwas extracted with DCM
  2. dry with materialThe organics were dried over MgSO4
  3. concentrationconcentrated
  4. customPurification of the crude residue by silica gel column chromatography (0 to 100% EtOAc/heptane)

Quellen und Nachweise

ORD-Eintrag
ord-4c79b97521bf4dbaa0dbc838e75f0a0e
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09012443B2

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