HCID 86672573, Verbindung → 4-(2-Methanesulfonyl-ethyl)-3-(2-m-tolyl-ethoxy)-benzoic Acid Methyl Ester

HRID 1475803Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1475803
[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:5]=1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:5]=1

Komponenten

5

Edukt 2

HCID 86672573HCID 86672573, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 671694814-(2-Methanesulfonyl-ethyl)-3-(2-m-tolyl-ethoxy)-benzoic Acid Methyl EsterAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

250 mg of 4-((E)-2-Methanesulfonyl-vinyl)-3-(2-m-tolyl-ethoxy)-benzoic acid methyl ester were dissolved using 10 ml of methanol and hydrogenated under an 1.5 bar atmosphere of hydrogen using 50 mg of Pd/C (10%, 50% water) for 30 minutes. The catalyst was then removed by filtration and the solution evaporated to yield 250 mg of the title compound that was used without further purification.

Aufarbeitung

  1. customThe catalyst was then removed by filtration
  2. customthe solution evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d5e6544ed1e84e8e93f870acd9b345e3
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09018383B2

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