Leucinamide hydrochloride → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

HRID 1477793

Reaktionsgleichung

Reaktionsgleichung von HRID 1477793
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C@@H:20]([CH2:24][CH:25]([CH3:27])[CH3:26])[C:21]([NH2:23])=[O:22]>>[C:21]([C@@H:20]([NH:19][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[CH2:24][CH:25]([CH3:27])[CH3:26])(=[O:22])[NH2:23]

Komponenten

3

Edukt 2

HCID 2733199Leucinamide hydrochlorideHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Produkt 1

HCID 715257635-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and (2S)-2-amino-4-methyl-pentanamide hydrochloride (1:1) (CAN 10466-61-2) as starting materials, and isolated (46 mg, 62%) as light yellow gum; LC-MS (UV peak area, ESI) 100%, 347.2081 (M+H).

Aufarbeitung

  1. customisolated (46 mg, 62%) as light yellow gum

Quellen und Nachweise

ORD-Eintrag
ord-1e57a45542a34008bd4b17c43bd54d73
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09403808B2

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