HCID 86705039, Verbindung → 6-Fluoro-1H-indol-4-amine

HRID 1477840Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1477840
[F:1][C:2]1[CH:7]=[C:6]([N+]([O-])=O)[C:5]([CH:11]=[CH:12][N:13](C)C)=[C:4]([N+:16]([O-])=O)[CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]2[CH:11]=[CH:12][NH:13][C:6]=2[CH:7]=1

Komponenten

4

Edukt 1

HCID 86705039HCID 86705039, Verbindung

Produkt 1

HCID 247280226-Fluoro-1H-indol-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2-(4-fluoro-2,6-dinitrophenyl)-N,N-dimethylethenamine (18 g, 0.071 mol) was dissolved in ethanol (1000 mL), and charged with 10% palladium on carbon (2.0 g). The mixture was hydrogenated at room temperature overnight. The mixture was filtrated through celite and washed with ethanol. The filtrate was combined and evaporated in vacuo. The residue was purified by silica gel flash chromatography (PE: EA=2:1) to afford the title compound. LC/MS m/z=151.2 [M+H]+.

Aufarbeitung

  1. filtrationThe mixture was filtrated through celite
  2. washwashed with ethanol
  3. customevaporated in vacuo
  4. customThe residue was purified by silica gel flash chromatography (PE: EA=2:1)

Quellen und Nachweise

ORD-Eintrag
ord-d20c72390c04403f87606094a2851b4e
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09403807B2

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