Dimethylmaleic anhydride → 4,5-Dimethylpyridazine-3,6-diol

HRID 1479982

Reaktionsgleichung

Reaktionsgleichung von HRID 1479982
Cl.[NH2:2][NH2:3].[CH3:4][C:5]1=[C:6]([CH3:12])[C:7]([O:9][C:10]1=O)=[O:8]>O>[CH3:4][C:5]1[C:10](=[O:9])[NH:2][NH:3][C:7](=[O:8])[C:6]=1[CH3:12]

Komponenten

4

Edukt 2

HCID 13010Dimethylmaleic anhydrideHCID 115031Hydrazinium chloride

Produkt 1

HCID 2422804,5-Dimethylpyridazine-3,6-diolAusbeute 99,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The supension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).

Aufarbeitung

  1. temperatureat reflux for 16 h
  2. filtrationthe precipitate is filtered
  3. washwashed with water
  4. customdried at 40° C. under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-64e70e3e1f1f41f68cc34feb9f3895a4
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409871B2

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