1-Cyclopropyl-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethan-1-amine → 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid [1-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

HRID 1480092

Reaktionsgleichung

Reaktionsgleichung von HRID 1480092
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH:18]1([C:21]([NH2:29])([C:23]2[N:27]=[C:26]([CH3:28])[O:25][N:24]=2)[CH3:22])[CH2:20][CH2:19]1>>[CH:18]1([C:21]([NH:29][C:10]([C:7]2[CH:6]=[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)[C:4]([CH:1]3[CH2:2][CH2:3]3)=[CH:9][N:8]=2)=[O:12])([C:23]2[N:27]=[C:26]([CH3:28])[O:25][N:24]=2)[CH3:22])[CH2:20][CH2:19]1

Komponenten

3

Edukt 2

HCID 435592231-Cyclopropyl-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethan-1-amineHCID 902038095-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Produkt 1

HCID 762829685-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid [1-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 1-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (CAN 1155536-64-3) as starting materials and isolated (13 mg, 23%) as colorless oil; MS (ESI, m/z): 383.6 (M+H+)

Aufarbeitung

  1. customisolated (13 mg, 23%) as colorless oil

Quellen und Nachweise

ORD-Eintrag
ord-c213e5fa60d44cf0b6306ced0f696d87
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409866B2

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