HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Amino-3-cyclopropylbutanamide → N-[4-amino-2-cyclopropyl-4-oxobutan-2-yl]-5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Amino-3-cyclopropylbutanamide | HCID 83681810 | — |
| Edukt | 5-(3,3-Difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)picolinic acid | HCID 90204045 | — |
| Produkt | N-[4-amino-2-cyclopropyl-4-oxobutan-2-yl]-5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide | HCID 90204877 | — |
Reaktionsschritte
The title compound was synthesized in analogy to Example 112e, using 5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (example 223b) and 3-amino-3-cyclopropyl-butanamide (example 270c) as starting materials and isolated (70 mg, 63%) as a racemate; MS (ESI, m/z): 437.3 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09409866B2 |
| Quelldatensatz | uspto-grants-2016_08 |
| ORD ID | ord-1d3439573eb940859541f572a3e3fec2 |
| Quellennotiz | uspto-grants-2016_08 |