4-Toluenesulfonyl chloride → HCID 89996125, Verbindung

HRID 1480815Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1480815
[I:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7][CH2:8][OH:9])[CH:6]=1.C(N(CC)CC)C.[S:17](Cl)([C:20]1[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=1)(=[O:19])=[O:18]>C(Cl)Cl>[CH3:24][C:23]1[CH:25]=[CH:26][C:20]([S:17]([O:9][CH2:8][CH2:7][N:5]2[CH:6]=[C:2]([I:1])[CH:3]=[N:4]2)(=[O:19])=[O:18])=[CH:21][CH:22]=1

Komponenten

5

Edukt 3

HCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 578867372-(4-Iodo-1H-pyrazol-1-yl)ethanol

Produkt 1

HCID 89996125HCID 89996125, VerbindungAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-(4-Iodo-1H-pyrazol-1-yl)ethanol (Preparation 57, 535 mg, 2.248 mmol) in DCM (11 mL) was treated with triethylamine (1.55 mL, 11.14 mmol) at 0° C. Tosyl chloride (857 mg, 4.50 mmol) was added at 0° C. and the mixture was allowed to warm to room temperature for 18 hours. The organic layer was washed with water, HCl 1M and water (twice). The organic layers were dried, concentrated and purified by silica gel column chromatography eluting with 0 to 30% EtOAc in cyclohexane to give the title compound (817 mg, 93%).

Aufarbeitung

  1. washThe organic layer was washed with water, HCl 1M and water (twice)
  2. customThe organic layers were dried
  3. concentrationconcentrated
  4. custompurified by silica gel column chromatography
  5. washeluting with 0 to 30% EtOAc in cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-b985b8e7aacc4b73828f8e2fee40dcce
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409907B2

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