Lithium iodide → HCID 71282062, Verbindung

HRID 1481684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1481684
[CH2:1]([C:3]1[C:4]([OH:25])=[C:5]([C:21]([O:23]C)=[O:22])[C:6](=[O:20])[NH:7][C:8]=1[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH3:19])[CH2:14][CH2:13][CH2:12]2)[CH3:2].[I-].[Li+]>CCOC(C)=O>[CH2:1]([C:3]1[C:4]([OH:25])=[C:5]([C:21]([OH:23])=[O:22])[C:6](=[O:20])[NH:7][C:8]=1[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH3:19])[CH2:14][CH2:13][CH2:12]2)[CH3:2]

Komponenten

4

Edukt 2

HCID 66321Lithium iodideHCID 71284563HCID 71284563, Verbindung

Produkt 1

HCID 71282062HCID 71282062, VerbindungAusbeute 61 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

To a suspension of methyl 5-ethyl-4-hydroxy-6-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-oxo-1,2-dihydropyridine-3-carboxylate (34 mg, 0.1 mmol) in EtOAc (1 mL) was added lithium iodide (40 mg, ca. 0.3 mmol, 3.0 eq) at room temperature. The mixture was heated to 65° C. and stirred for 1 h. The reaction mixture was diluted by EtOAc (2 mL) then quenched with 1N HCl (0.5 mL). The precipitate was collected by filtration then washed with Et2O to afford the title compound as a yellow solid (20 mg, 0.061 mmol, 61%).

Aufarbeitung

  1. customthen quenched with 1N HCl (0.5 mL)
  2. filtrationThe precipitate was collected by filtration
  3. washthen washed with Et2O

Quellen und Nachweise

ORD-Eintrag
ord-d65a66f24a76462198d42ae14b4f433d
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409905B2

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