Sodium Hydroxide → 2-(4-Chlorophenyl)cyclobutanone oxime
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:11][CH2:10][C:9]2=O)=[CH:4][CH:3]=1.Cl.[NH2:14][OH:15].[OH-].[Na+]>CCO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:11][CH2:10][C:9]2=[N:14][OH:15])=[CH:4][CH:3]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 2-(4-chlorophenyl)cyclobutanone (1.122 g, 6.09 mmol), hydroxylamine hydrochloride (3.541 g. 8.2 eq.) and 36 ml of 5% NaOH in 30 ml EtOH was heated at reflux for 2 h. The solution was cooled, adjusted to pH 6, and extracted with CHCl3. The organic extract was washed with brine and dried. Filtration and concentration yielded 2-(4-chlorophenyl)cyclobutanone oxime as an oil. 1 g (84%)
Aufarbeitung
- temperatureat reflux for 2 h
- temperatureThe solution was cooled
- extractionextracted with CHCl3
- extractionThe organic extract
- washwas washed with brine
- customdried
- filtrationFiltration and concentration
Quellen und Nachweise
- ORD-Eintrag
- ord-5cb33c3b4ce54ca58200a6b306d41575
- Quelldatensatz
- uspto-grants-2016_08
- Patentnummer
- US09414589B2
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