N,N-dimethyl-4-nitrobenzenesulfonamide → Benzenesulfonamide, 4-amino-N,N-dimethyl-

HRID 1484832

Reaktionsgleichung

Reaktionsgleichung von HRID 1484832
[CH3:1][N:2]([CH3:15])[S:3]([C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1)(=[O:5])=[O:4]>CO.[Pd]>[NH2:12][C:9]1[CH:10]=[CH:11][C:6]([S:3]([N:2]([CH3:15])[CH3:1])(=[O:5])=[O:4])=[CH:7][CH:8]=1

Komponenten

4

Edukt 1

HCID 2747580N,N-dimethyl-4-nitrobenzenesulfonamide

Produkt 1

HCID 74369Benzenesulfonamide, 4-amino-N,N-dimethyl-Ausbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Under H2, N,N-dimethyl-4-nitrobenzenesulfonamide (879 mg, 3.8 mmol, 1.0 equiv.) was catalytically hydrogenated in the presence of Pd/C (40 mg) in MeOH (25 mL). When no more H2 was consumed, the reaction mixture was filtered. The filtrate was concentrated and crystallized to afford compound 4-amino-N,N-dimethyl benzenesulfonamide (722 mg, 95%).

Aufarbeitung

  1. customWhen no more H2 was consumed
  2. filtrationthe reaction mixture was filtered
  3. concentrationThe filtrate was concentrated
  4. customcrystallized

Quellen und Nachweise

ORD-Eintrag
ord-516b0c9b1bff4851872f7983c660b89c
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09422271B2

Verknüpfte Notizen

Wird geladen…