n-Cyclohexylpiperidine-4-carboxamide → HCID 86706526, Verbindung

HRID 1486697

Reaktionsgleichung

Reaktionsgleichung von HRID 1486697
ClC1C([N+]([O-])=O)=CC=CC=1C=O.C1(NC(C2CCNCC2)=O)CCCCC1.[CH:28]1([NH:34][C:35]([CH:37]2[CH2:42][CH2:41][N:40]([CH2:43][C:44]3[CH:49]=[CH:48][CH:47]=[C:46]([N+:50]([O-])=O)[C:45]=3[Cl:53])[CH2:39][CH2:38]2)=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH:28]1([NH:34][C:35]([CH:37]2[CH2:42][CH2:41][N:40]([CH2:43][C:44]3[CH:49]=[CH:48][CH:47]=[C:46]([NH2:50])[C:45]=3[Cl:53])[CH2:39][CH2:38]2)=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1

Komponenten

4

Edukt 3

HCID 12410238n-Cyclohexylpiperidine-4-carboxamideHCID 126677132-Chloro-3-nitrobenzaldehydeHCID 867065271-(2-Chloro-3-nitro-benzyl)-piperidine-4-carboxylic acid cyclohexylamide

Produkt 1

HCID 86706526HCID 86706526, Verbindung

Versuchsvorschrift

The title compound is prepared according to the reactions described above starting from 2-chloro-3-nitro-benzaldehyde and piperidine-4-carboxylic acid cyclohexylamide giving after reductive amination 1-(2-chloro-3-nitro-benzyl)-piperidine-4-carboxylic acid cyclohexylamide LC-MS B: tR=0.57 min; [M+H]+=380.14 and reduction with stannous chloride the title compound LC-MS A: tR=0.50 min; [M+H]+=350.20.

Aufarbeitung

  1. customThe title compound is prepared

Quellen und Nachweise

ORD-Eintrag
ord-f2b5c8cf9e8b451690eb334efb45e56a
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428456B2

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