Triethylsilane → HCID 89815378, Verbindung

HRID 1487116Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1487116
[F:1][C:2]([F:15])([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)[C:3]([NH2:5])=[O:4].C([SiH](CC)CC)C>CO.[Pd]>[NH2:12][C:8]1[CH:7]=[C:6]([C:2]([F:1])([F:15])[C:3]([NH2:5])=[O:4])[CH:11]=[CH:10][CH:9]=1

Komponenten

5

Edukt 2

HCID 12052TriethylsilaneHCID 89815111HCID 89815111, Verbindung

Produkt 1

HCID 89815378HCID 89815378, VerbindungAusbeute 69,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 2,2-difluoro-2-(3-nitrophenyl)acetamide (0.5 g, 2.313 mmol) in methanol (20 ml) was added Pd—C (100 mg) followed by slow addition of triethylsilane (3.7 ml, 23.13 mmol) at RT. The reaction was stirred at same temperature for 30 min. The reaction mixture was filtered through celite bed and washed with methanol (50 ml). Filtrate was collected and concentrated under vacuum to get 2-(3-aminophenyl)-2,2-difluoroacetamide (0.301 g).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite bed
  2. washwashed with methanol (50 ml)
  3. customFiltrate was collected
  4. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e965fd3680d4426a8ddc72ce79c6bdb7
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428499B2

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