Triethylsilane → 3-((4-Methyl-1-piperazinyl)carbonyl)aniline

HRID 1487151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1487151
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=2)=[O:9])[CH2:4][CH2:3]1.C([SiH](CC)CC)C>CO.[Pd]>[NH2:16][C:12]1[CH:11]=[C:10]([C:8]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[O:9])[CH:15]=[CH:14][CH:13]=1

Komponenten

5

Edukt 2

HCID 12052TriethylsilaneHCID 763411(4-Methylpiperazin-1-yl)(3-nitrophenyl)methanone

Produkt 1

HCID 167732183-((4-Methyl-1-piperazinyl)carbonyl)anilineAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a stirred solution of (4-methylpiperazin-1-yl)(3-nitrophenyl)methanone (5.5 g, 22.06 mmol) in MeOH (50 ml) was added Pd—C (10%, 0.470 g) followed by triethylsilane (14.10 ml, 88 mmol) (slow addition) at RT. The reaction mixture was stirred at same temperature for 25 min and filtered through celite, washed with methanol (50 ml). The Filtrate was concentrated under vacuum to get the title product (4.11 g).

Aufarbeitung

  1. filtrationfiltered through celite
  2. washwashed with methanol (50 ml)
  3. concentrationThe Filtrate was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ec4c6f4b15364f1c9ba93fb08e74acc5
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428499B2

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