Hydrochloric Acid → 5-Bromo-3-chloro-2-hydrazinylpyrazine
Reaktionsgleichung
[Br:1][C:2]1[N:3]=[C:4]([Cl:16])[C:5]([NH:8][NH:9]C(=O)C(F)(F)F)=[N:6][CH:7]=1.Cl.C([O-])(O)=O.[Na+]>CCO.O>[Br:1][C:2]1[N:3]=[C:4]([Cl:16])[C:5]([NH:8][NH2:9])=[N:6][CH:7]=1Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
N′-(5-bromo-3-chloropyrazin-2-yl)-2,2,2-trifluoroacetohydrazide G-1 (1.59 g; 4.97 mmol) is dissolved in 30 ml EtOH and treated with 3 ml conc. HCl. It is stirred for 2 hours at 100° C. The reaction mixture is cooled down, diluted with water and then the pH adjusted to 8 with saturated NaHCO3 solution. The water phase is extracted with EtOAc, the organic layer dried over MgSO4 and evaporated to dryness.
Aufarbeitung
- temperatureThe reaction mixture is cooled down
- extractionThe water phase is extracted with EtOAc
- dry with materialthe organic layer dried over MgSO4
- customevaporated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-9f18484fabf046debf869f1a98bb4eae
- Quelldatensatz
- uspto-grants-2016_08
- Patentnummer
- US09428513B2
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