Sodium Methoxide → HCID 90021327, Verbindung

HRID 1488173Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1488173
[O:1]1[CH2:5][CH2:4][CH:3]([C:6](=[O:9])[CH2:7][CH3:8])[CH2:2]1.[CH3:10][O-:11].[Na+]>C(OCC)=O>[CH3:8][CH:7]([C:6](=[O:9])[CH:3]1[CH2:4][CH2:5][O:1][CH2:2]1)[CH:10]=[O:11]

Komponenten

4

Edukt 2

HCID 10942334Sodium MethoxideHCID 21702750HCID 21702750, Verbindung2×

Produkt 1

HCID 90021327HCID 90021327, VerbindungAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8025Ethyl formateLösungsmittel

Versuchsvorschrift

Into a 100-mL round-bottom flask, was placed 1-(tetrahydrofuran-3-yl)propan-1-one (compound 263.2, 2.5 g, 19.5 mmol), sodium methoxide (1.4 g, 25.9 mmol) and ethyl formate (20 mL). The mixture was stirred overnight at room temperature, then concentrated under reduced pressure. The residue was purified by a silica gel column chromatography with ethyl acetate/petroleum ether (1:20 to 1:5) as eluent to obtain the title compound as a yellow solid (2.0 g, 66%).

Aufarbeitung

  1. customInto a 100-mL round-bottom flask, was placed
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by a silica gel column chromatography with ethyl acetate/petroleum ether (1:20 to 1:5) as eluent

Quellen und Nachweise

ORD-Eintrag
ord-3ab0b34df5c24500a7d02cc7d3e1aad8
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428502B2

Notizen zur Reaktion

Wird geladen…