2-Chloroethanol → 1-Chloro-3-(2-chloroethoxy)propan-2-ol

A mixture consisting of 100 g 2-chloroethanol (12.4 mol), 573 g epichlorohydrin (6.2 mol) and 20 g of an acidic ion exchange resin was refluxed for 24 hours. The mixture was then filtered to remove the ion exchange resin and the excess alcohol and unreacted epichlorohydrin were removed by distillation. The residue was distilled under vacuum and the product 1-chloro-3-(2-chloroethoxy)-2-propanol (804 g, 75% yield) distilled between 89° and 91° C. at 0.05 mm Hg.

1. temperaturewas refluxed for 24 hours
2. filtrationThe mixture was then filtered
3. customto remove the ion exchange resin
4. customthe excess alcohol and unreacted epichlorohydrin were removed by distillation
5. distillationThe residue was distilled under vacuum

ORD-Eintrag

ord-229a581b96784722b91e2508b8cfd949

Quelldatensatz

uspto-grants-1997_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05674949