Morpholine → HCID 11062669, Verbindung
Reaktionsgleichung
[C:1](OCC)(=[O:5])[C@H:2]([CH3:4])[OH:3].[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[OH:3][C@@H:2]([CH3:4])[C:1]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)=[O:5]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
A mixture of 75 g of (S)-ethyl lactate and 164 g of morpholine was heated at 80° C. for 64 hours. The reaction solution was concentrated and purified by silica gel chromatography (eluent; hexane:ethyl acetate=4:1 to ethyl acetate) to give 69.4 g of 4-[(S)-2-hydroxypropionyl]morpholine as a pale yellow oil.
Aufarbeitung
- concentrationThe reaction solution was concentrated
- custompurified by silica gel chromatography (eluent; hexane:ethyl acetate=4:1 to ethyl acetate)
Quellen und Nachweise
- ORD-Eintrag
- ord-95031e7cfbeb4d218c5cdad1654d3006
- Quelldatensatz
- uspto-grants-1997_10
- Patentnummer
- US05677464
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